| Date | Location | Result | |
| Nov 13, 2021 | Fairfield, Ala. | Albany State 31, Miles 0 | Box score |
| Nov 06, 2021 | Savannah, Ga. | Savannah State 24, Edward Waters 0 | Box score |
| Nov 06, 2021 | Atlanta, Ga. | Morehouse 35, Clark Atlanta 26 | Box score |
| Nov 06, 2021 | Frankfort, Ky. | Kentucky State 63, Central State 0 | Box score |
| Nov 06, 2021 | Columbia, S.C. | Benedict 34, Lane 30 | Box score |
| Nov 06, 2021 | Columbus, Ga. | Albany State 57, Fort Valley State 0 | Box score |
| Nov 06, 2021 | Fairfield, Ala. | Miles 52, Tuskegee 23 | Box score |
| Oct 30, 2021 | Jacksonville, Fla. | Miles 16, Edward Waters 9 | Box score |
| Oct 30, 2021 | Atlanta, Ga. | Albany State 14, Morehouse 10 | Box score |
| Oct 30, 2021 | Fort Valley, Ga. | Savannah State 24, Fort Valley State 6 | Box score |
| Oct 30, 2021 | Wilberforce, Ohio | Lane 16, Central State 14 | Box score |
| Oct 30, 2021 | Tuskegee, Ala. | Kentucky State 42, Tuskegee 35 | Box score |
| Oct 30, 2021 | Atlanta, Ga. | Benedict 24, Clark Atlanta 21 | Box score |
| Oct 30, 2021 | Blythewood, S.C. | Allen 32, Columbus State 25 | Box score |
| Oct 23, 2021 | Albany, Ga. | Albany State 30, Savannah State 0 | Box score |
| Oct 23, 2021 | Jacksonville, Fla. | Edward Waters 56, Central State 19 | Box score |
| Oct 23, 2021 | Greenwood, S.C. | Erskine 47, Allen 40 | Box score |
| Oct 23, 2021 | Fort Valley, Ga. | Fort Valley State 40, Clark Atlanta 7 | Box score |
| Oct 23, 2021 | Columbia, S.C. | Morehouse 20, Benedict 5 | Box score |
| Oct 23, 2021 | Frankfort, Ky. | Miles 28, Kentucky State 21 | Box score |
| Oct 23, 2021 | Tuskegee, Ala. | Lane 21, Tuskegee 17 | Box score |
| Oct 16, 2021 | Jacksonville, Fla. | Kentucky State 76, Edward Waters 36 | Box score |
| Oct 16, 2021 | Savannah, Ga. | Savannah State 49, Clark Atlanta 14 | Box score |
| Oct 16, 2021 | Jackson, Tenn. | Miles 34, Lane 31 | Box score |
| Oct 16, 2021 | Atlanta, Ga. | Morehouse 51, Fort Valley State 3 | Box score |
| Oct 16, 2021 | Columbia, S.C. | Albany State 28, Benedict 6 | Box score |
| Oct 16, 2021 | Wilberforce, Ohio | Tuskegee 29, Central State 0 | Box score |
| Oct 09, 2021 | Frankfort, Ky. | Kentucky State 49, Lane 14 | Box score |
| Oct 09, 2021 | Birmingham, Ala. | Morehouse 31, Tuskegee 15 | Box score |
| Oct 09, 2021 | Savannah, Ga. | Savannah State 39, Erskine College 6 | Box score |
| Oct 09, 2021 | Albany, Ga. | Albany State 30, Edward Waters 0 | Box score |
| Oct 09, 2021 | Fort Valley, Ga. | Fort Valley State 35, Central State 14 | Box score |
| Oct 09, 2021 | Fairfield, Ala. | Benedict 24, Miles 21 | Box score |
| Oct 09, 2021 | Atlanta, Ga. | Clark Atlanta 21, Allen 12 | Box score |
| Oct 02, 2021 | Tuskegee, Ala. | Tuskegee 21, Clark Atlanta 0 | Box score |
| Oct 02, 2021 | Atlanta, Ga. | Edward Waters 37, Morehouse 13 | Box score |
| Oct 02, 2021 | Jackson, Tenn. | Lane 71, Texas College 0 | Box score |
| Oct 02, 2021 | Frankfort, Ky. | Savannah State 21, Kentucky State 17 | Box score |
| Oct 02, 2021 | Columbia, S.C. | Fort Valley State 24, Benedict 14 | Box score |
| Oct 02, 2021 | Fairfield, Ala. | Albany State 31, Miles 3 | Box score |
| Oct 02, 2021 | Wilberforce, Ohio | Allen 46, Central State 34 | Box score |
| Sep 25, 2021 | Fairfield, Ala. | Miles 55, Central State 4 | Box score |
| Sep 25, 2021 | Jacksonville, Fla. | Lane 45, Edward Waters 35 | Box score |
| Sep 25, 2021 | Blythewood, S.C. | Fort Valley State 56, Allen 20 | Box score |
| Sep 25, 2021 | Indianapolis, Ind. | Kentucky State 34, Benedict 28 | Box score |
| Sep 25, 2021 | Mobile, Ala. | Alabama A&M 45, Tuskegee 35 | Box score |
| Sep 25, 2021 | Albany, Ga. | Albany State 49, Clark Atlanta 0 | Box score |
| Sep 25, 2021 | Savannah, Georgia | Savannah State 29, Morehouse 10 | Box score |
| Sep 18, 2021 | Nashville, Tenn. | Tennessee State 41, Kentucky State 7 | Box score |
| Sep 18, 2021 | Valdosta, Ga. | Valdosta State 21, Albany State 3 | Box score |
| Sep 18, 2021 | Blythewood, S.C. | Allen 34, Livingstone 32 | Box score |
| Sep 18, 2021 | Savannah, Ga. | Savannah State 41, Benedict 34 | Box score |
| Sep 18, 2021 | Tuskegee, Ala. | Tuskegee 23, Edward Waters 6 | Box score |
| Sep 18, 2021 | Raleigh, N.C. | Shaw 52, Central State 0 | Box score |
| Sep 18, 2021 | Atlanta, Ga. | Shorter 38, Clark Atlanta 17 | Box score |
| Sep 18, 2021 | Atlanta, Ga. | Miles 37, Morehouse 14 | Box score |
| Sep 18, 2021 | Fort Valley, Ga. | Lane 27, Fort Valley State 24 | Box score |
| Sep 11, 2021 | Frankfort, Ky. | Kentucky Wesleyan 26, Kentucky State 25 | Box score |
| Sep 11, 2021 | Tallahassee, Fla. | Florida A&M 34, Fort Valley State 7 | Box score |
| Sep 11, 2021 | Baton Rouge, La. | Southern 41, Miles 24 | Box score |
| Sep 11, 2021 | Coatesville, Pa. | Central State 19, Lincoln (Pa.) 7 | Box score |
| Sep 11, 2021 | Albany, Ga. | Albany State 28, Shorter 12 | Box score |
| Sep 11, 2021 | Carrollton, Ga. | West Georgia 47, Morehouse 0 | Box score |
| Sep 11, 2021 | Tuskegee, Ala. | West Alabama 33, Tuskegee 7 | Box score |
| Sep 11, 2021 | Savannah, Ga. | Savannah State 50, Livingstone 6 | Box score |
| Sep 11, 2021 | Atlanta, Ga. | Lane 35, Clark Atlanta 26 | Box score |
| Sep 11, 2021 | Charlotte, N.C. | Allen 20, Johnson C. Smith 19 | Box score |
| Sep 09, 2021 | Columbia, S.C. | Benedict 44, Edward Waters 3 | Box score |
| Sep 05, 2021 | Montgomery, Ala. | Fort Valley State 30, Tuskegee 0 | Box score |
| Sep 04, 2021 | Montgomery, Ala. | Alabama State 14, Miles 13 | Box score |
| Sep 04, 2021 | Salisbury, N.C. | Clark Atlanta 13, Livingstone 10 | Box score |
| Sep 04, 2021 | Columbia, S.C. | Benedict 45, Allen 12 | Box score |
| Sep 04, 2021 | Valdosta, Ga. | Valdosta State 53, Savannah State 7 | Box score |
| Sep 04, 2021 | Pine Bluff, Ark. | Arkansas Pine Bluff 34, Lane 16 | Box score |
| Sep 02, 2021 | Clinton, Miss. | Albany State 24, Mississippi Col. 0 | Box score |
| Aug 28, 2021 | Jacksonville, Fla. | Edward Waters 24, Florida Memorial 20 | Box score |
| Aug 28, 2021 | Columbus, Ohio | Kentucky State 20, Central State 6 | Box score |